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  • Introduction
  • Agenda
  • Single Molecule, Real Time (SMRT) DNA Sequencing
  • SMRT Raw Data Trace
  • Prerequisite for Whole-Genome Epigenetics
  • Kinetics in SMRT DNA Sequencing
  • Interpulse Duration vs. Sequence Context
  • Detection of DNA Base Modifications by SMRT Sequencing
  • Detection of DNA
  • How Many Bases Can Influence Kinetics at One Position?
  • Kinetics Vary With Sequence, But Reproducibly
  • Workflow to Analyze Kinetic Information
  • Base Modification SMRT Portal Reports
  • Whole Genome Bacterial DNA Motif Detection
  • Methylome Visualization
  • DNA Base Modifications Detectable by SMRT Sequencing
  • The Three (Common) Prokaryotic Epigenetic Modifications
  • Enhancing the Kinetic Signal for 5-Methylcytosine
  • Enhancing the Kinetic Signal for 5-Methylcytosine: E. coli
  • Characterization of Methyltransferases
  • Base Modification Detection Publications
  • Agenda
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  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio