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  • Introduction
  • Repeated DNA Sequences in Eukaryotic Genomes and Mechanisms of Evolution
  • Uniqueness of K-mer is Genomes & Lander Waterman Statistics
  • One Small Example: A Short, but Hard to Resolve Region: KIR
  • Simulations for Assembly with Short-Read Data
  • PacBio® Assembly Results for the KIR Fosmid from 1/50th SMRT® Cell
  • Hierarchical Genome Assembly Process
  • Construct High-Confidence, Pre-Assembled Long Reads
  • Accuracy and Read Length Through HGAP
  • Close to Finished Genome with Single Library
  • Beyond Bacteria
  • High K-mer Count Indicates Some Repeats
  • What Are Those High Abundance K-mers?
  • "Repeticon"
  • Different Arrangements of the Repeticons Along Two PacBio® Reads
  • Alignment Between the Two Reads
  • An Intriguing Contig (39 PacBIo® PLRs Contribute to the Contig)
  • Hard to Assemble with (Simulated) Short Reads
  • Some Intriguing Tandem Repeats
  • PacBio® Assembly Resolves the Palindrome Junction in Difficult to Assemble Plant BAC
  • Ability to Sequence Through Extreme CG-Rich Content
  • The Mission to Decode Full Genomes
  • Acknowledgment
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  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio
  • Speaker: Jason Chin, PhD / PacBio