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  • Introduction
  • Outline
  • Collaborators
  • H. pylori infection and its clinical consequences
  • Helicobacter pylori microbiology
  • Sources of genetic diversity in H. pylori
  • Quantitiative parameters of recombination /mutation in H. pylori
  • Non-random distribution of import events
  • H. pylori strains 26695 and J99: First bacterial intra species genome comparison
  • H. pylori restriction-modification systems
  • Outline
  • Detection of methylation across the H. pylori genomes
  • The methylomes of H. pylori 26695 and J99-R3
  • Differential methylation of homologous sequences
  • Outwards to inwards
  • Inactivation of MTase genes by allelic disruption
  • J99 - R3jjhp0085 Example
  • Outline
  • Assigning novel methylation patterns to MTases I
  • Cloning and expression of candidate genes
  • Characterization of methylation activity
  • Assigning novel methylation patterns to MTases II
  • Unusual activities of H. pylori Type I R-M systems
  • JHP1422 displays allelic heterogeneity affecting specificity
  • Unusual activities of H. pylori Type I R-M systems: JHP0785/0786
  • Possible interaction of JHP0786 MTase with two S-subunits
  • Summary
  • Thank You
  • Q & A
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  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
  • Speaker: Sebastian Suerbaum, Prof. Dr. / Hannover Medical School
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