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  • Introduction
  • Host adopted bacterial pathogens
  • Surface expressed virulence factors
  • Phase variation
  • Phase variation via simple tandem repeats
  • Phase variation - a powerful system for generating phenotypic diversity
  • Avogadro and the memingococcus
  • Tetranucleotide repeats in Haemophilus influenzae
  • Type III Restriction - Modification Systems
  • Organisms containing phase variable type III restriction modification systems - why?
  • Phase variable R-M systems
  • Phase variable H. influenzae type III mod gene
  • Microarray expression profiling
  • Array results
  • Phase variation of a single gene vs the phase variable regulon - "Phasevarion"
  • Array results - 2 outer membrane proteins
  • Array results
  • What about the other pathogens
  • Organisms containing phase variable type III restriction modification systems
  • Neisseria meningitidis
  • Differently expressed genes in N. meningitidis WT MC58 mod ON versus the mod A11:: Kan mutant
  • LbpAB uptake system of Neisseria meningitidis
  • LbpB expression is controlled by Mod phase variation
  • Phenotypic analysis of Ng mod13 ON/OFF strains
  • Summary review of phasevarion ranges
  • Evidence for methylation?
  • How do changes in methylation regulate gene expression
  • SMRT methylome analysis was performed by our collaborators at PacBio on pairs of wild type and mod knockout strains
  • How do changes in methylation regulate gene expression?
  • Mapping methylation sites to promoter regions
  • A phase variable regulon - "Phasevarion"
  • Acknowledgments
  • Q & A
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  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University
  • Speaker: Michael Jennings, PhD / Griffith University