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  • Introuction
  • Allen D. Roses Commemoration
  • Allen Roses Interview
  • Agenda
  • ~1,800 publications
  • Structural variants contribute to disease, traits, and evolution
  • Map of PacBio De Novo human genomes
  • Pacbio De Novo Chinese Human Genome Assembly
  • Pacbio De Novo Korean Human Genome Assembly
  • Many structural variants remain to be discovered
  • Variant discovery does not require deep sequencing of every individual
  • SV Discovery with Low-fold PacBio Coverage
  • NA12878
  • SV Discovery with Low-fold PacBio Coverage
  • NA12878 10-Fold SV Call Set
  • Library Recommendation for SV Discovery
  • NA12878 10-Fold SV Call Set
  • Reference-based SV Discovery
  • Ecosystem Developed Around the Illumina Platform
  • Typical IGV Usage
  • Baseline IGV View
  • Improved IGV View
  • “Quick Phase” by Grouping by Base Pair at Position
  • IGV with PacBio Support Enabled
  • Structural Variant Discovery: Deletion
  • Structural Variant Discovery: Insertion
  • PacBio Support is Available in the IGV Dev Build
  • Sequel Update
  • Comparison to Other Technologies
  • Variation Call Differences
  • CHR1:179,040,442-179,040,668
  • All Other Sites
  • Variation Call Differences
  • CHR16:81,265,766-81,265,874
  • All Other Sites
  • Variation Call Differences
  • Phased, Diploid PacBio De Novo Genome Assemblies
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  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio
  • Speaker: Jonas Korlach, PhD / PacBio