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  • Introduction
  • KIR Workshop 2015
  • Structure of KIR
  • Why we're interested in the KIR region
  • Fully Sequenced KIR Haplotypes
  • Structural Characteristics
  • N=506 European Americans; 14 KIR loci
  • KIR Structures 2010
  • Centromeric, Telomeric and Additional Haplotypes
  • Haplotype Frequencies
  • Presence/Absence Results
  • Centromeric Motif and Telomeric Motif
  • Structures 12-71
  • Haplotype #Chrom. (freq)
  • Genomic Reference Consortium
  • Dot Plots - Useful Tools for De-convoluting Structural Variation
  • Haplotype with fusion gene
  • KIR Graph
  • Simple KIR Graph
  • Energetic Region
  • SMRT® Sequencing for KIR Genotyping ad Haplotyping
  • Recombination Probe Based 40Kb Fosmid Capture
  • Shotgun Sequencing of Individual Fosmids on PacBio RS II
  • Simpler Workflow: Haplotype Sequencing Using Pooled Fosmids
  • Reads Spanning ~ 40 kb Generated on PacBio RS II
  • 8 Sample Pilot
  • Haplotypes Sequenced
  • Acknowledgement
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  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP
  • Speaker: Martin Maiers, Bioinformatics / NMDP