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  • Introduction
  • Spinocerebellar ataxia type 10 (SCA10)
  • SCA10 genetics
  • Not pure ATTCT… …RP-PCR
  • What about the rest of the expansion?
  • SMRT sequencing of SCA10 expansions …round 1
  • What is a SCA10 expansion?
  • Conclusions… so far
  • Can we purify enough expansion sequence?
  • CRISPR-Cas9
  • Target enrichment via Cas9
  • Parkinson's Case
  • Conclusions
  • Many thanks…
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  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida
  • Speaker: Karen McFarland, Research Assistant Professor / College of Medicine, Department of Neurology, University of Florida