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  • Introduction
  • Disclosures
  • Why study the genomes of the great apes?
  • Great Ape Assemblies
  • Repetitive sequence makes assembly difficult.
  • “3rd Generation” Sequencing Technology:
PacBio Single Molecule, Real-Time (SMRT) Sequencing
  • Goal
  • Previous gorilla assembly (gorGor3)
  • New gorilla assembly (Susie3)
  • 74.8-fold coverage of P6C4 (@3.0 Gbp genome size)
  • Susie3 shows over 800-fold improvement in contiguity.
  • Detecting mis-assemblies
  • Susie3 closes majority (94%) of gorGor3 gaps.
  • 87% (11,105/12,754) of missing RefSeq exons in gorGor3 gaps are recovered in Susie3.
  • Susie3 corrects mis-assembled MHC Class II locus.
  • Fine scale novel structural variation.
  • Proportion of full-length retrotransposons (PTERV1) is significantly greater in Susie3.
  • Sequence-resolved complex gorilla genome structural variation.
  • Refine population estimates.
  • Summary
  • Great Ape Assemblies
  • Acknowledgements
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  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine
  • Speaker: Christopher Hill, Senior Fellow, Eichler Lab / University of Washington School of Medicine